Paramecium is a unicellular eukaryote of large size (120 micrometers) that belongs to the ciliate phylum. Ciliates share two characteristics: the presence of vibrating cilia which assure their locomotion and food capture, and nuclear dimorphism. Indeed, ciliates, like multicellular eukaryotes, separate germinal and somatic functions, but they do so in the form of two different kinds of nuclei. A diploid germinal micronucleus transmits the genetic information to the next sexual generation, while a polyploid somatic macronucleus is responsible for gene expression.
The Paramecium tetraurelia macronuclear genome was recently sequenced by the Genoscope French National Sequencing Center.
ParameciumDB is a new model organism database associated with the genome sequencing project. Built with core components of the Generic Model Organism Database (GMOD) project, ParameciumDB currently contains the macronuclear genome sequence and annotations, linked to available genetic data (RNA interference data and stock collection).
Please cite ParameciumDB:
Arnaiz O and Sperling L 2011. ParameciumDB in 2011: new tools and new data for functional and comparative genomics of the model ciliate Paramecium tetraurelia. Nucleic Acids Res 39: Database issue D632-6. PMID: 20952411
Arnaiz et al. 2007. ParameciumDB: a community resource that integrates the Paramecium tetraurelia genome sequence with genetic data. Nucleic Acids Res 35: Database issue D439-D444. PMID: 17142227